Amygdala-pons connectivity is hyperactive and associated with symptom severity in depression.
Wong JJ, Wong NML, Chang DHF, Qi D, Chen L, Lee TMC.
Commun Biol. 2022 Jun 10;5(1):574.
Leung CJ, Yiend J, Trotta A, Lee TMC.
J Anxiety Discord. 2022 Jun; 89: 102575.
Physical Exercise Prevented Stress-Induced Anxiety via Improving Brain RNA Methylation.
Yan L, Wei JA, Yang F, Wang M, Wang S, Cheng T, Liu X, Jia Y, So KF, Zhang L.
Adv Sci (Weinh). 2022 Jun 1:e2105731.
Aberrant functional metastability and structural connectivity are associated with rumination in individuals with major disorder.
Zhang R, Tam STS, Wong NML, Wu J, Tao J, Chen L, Lin K, Lee TMC.
Neuroimage Clin. 2022;33:102916.
Understanding longevity in Hong Kong: a comparative study with long-living, high-income countries
Ni MY, Canudas-Romo V, Shi J, Flores FP, Chow MSC, Yao XI, Ho SY, Lam TH, Schooling CM, Lopez AD, Ezzati M, Leung GM.
Lancet Public Health. 2021 Dec;6(12):e919-e931.
Sleep promotes the formation of dendritic filopodia and spines near learning-inactive existing spines.
Adler A, Lai CSW, Lai CSW, Yang G, Geron E, Bai Y, Gan WB.
Proc Natl Acad Sci U S A. 2021 Dec 14;118(50):e2114856118.
Sleep’s short-term memory preservation and long-term affect depotentiation effect in emotional memory consolidation: behavioral and EEG evidence.
Zeng S, Lin X, Wang J, Hu X.
Sleep. 2021 Nov 12;44(11):zsab155.
Amyloid-β toxicity modulates tau phosphorylation through the PAX6 signalling pathway.
Zhang Y, Zhang Y, Aman Y, Ng CT, Chau WH, Zhang Z, Yue M, Bohm C, Jia Y, Li S, Yuan Q, Griffin J, Chiu K, Wong DSM, Wang B, Jin D, Rogaeva E, Fraser PE, Fang EF, St George-Hyslop P, Song YQ.
Brain. 2021 Oct 22;144(9):2759-2770. doi: 10.1093/brain/awab134. PMID: 34428276.
Integrative omics of schizophrenia: from genetic determinants to clinical classification and risk prediction.
Guan F, Ni T, Zhu W, Williams LK, Cui LB, Li M, Tubbs J, Sham PC, Gui H.
Mol Psychiatry. 2022 Jan;27(1):113-126. doi: 10.1038/s41380-021-01201-2. Epub 2021 Jun 30. PMID: 34193973.
Probable anxiety and components of psychological resilience amid COVID-19: A population-based study.
Hou WK, Tong H, Liang L, Li TW, Liu H, Ben-Ezra M, Goodwin R. & Lee TMC.
Journal of Affective Disorders. 2021, Mar 1; 282, 594-601.
The human posterior cingulate and the stress-response benefits of viewing green urban landscapes.
Chang DHF, Jiang B, Wong NHL, Wong JJ, Webster C, Lee TMC.
Neuroimage. 2021 Feb 1; 226: 117555.
Environmental enrichment or selective activation of parvalbumin-expressing interneurons ameliorates synaptic and behavioral deficits in animal models with schizophrenia-like behaviors during adolescence.
Huang Y, Zhang H, Zhang Q, Fok AHK, Li XY, Lau CG, Lai CSW.
Molecular Psychiatry. 2021 Jan 20; 26, pages 2533–2552.
A visual circuit related to the nucleus reuniens for the spatial-memory-promoting effects of light treatment.
Huang X, Huang P, Huang L, Hu Z, Liu X, Shen J, Xi Y, Yang Y, Fu Y, Tao Q, Lin S, Xu A, Xu F, Xue T, So KF, Li H, Ren C.
Neuron. 2021 Jan 20;109(2):347-362.e7.
The epidemiology of population mental wellbeing in China.
Ni MY, Leung CMC, Leung GM.
The Lancet Public Health. 2020 Dec; 5(12):E631-E632.
Determinants of Physical, Mental, and Social Well-Being: A Longitudinal Environment-Wide Association Study.
Ni MY, Yao XI, Cheung F, et al.
International Journal of Epidemiology. 2020 Apr 1;49(2):380-389.
Depression and post-traumatic stress during major social unrest in Hong Kong: a ten-year prospective cohort.
Ni MY, Yao XI, Leung KS, et al.
The Lancet. 2020 Jan; 395(10220):273-284.
REM sleep promotes experience-dependent dendritic spine elimination in the mouse cortex.
Zhou Y, Lai CSW, Bai Y, Li W, Zhao R, Yang G, Frank MG, Gan WB.
Nat Commun. 2020 Sep 23; 11(1):4819.
The implication of cognitive processes in emotional bias.
Lam CLM, Leung CJ, Yiend J, Lee TMC.
Neurosci Biobehav Rev. 2020 Jul; 114:156-157.
Connectome-based models can predict processing speed in older adults.
Gao M, Wong CHY, Huang H, Shao R, Huang R, Chan CCH, Lee TMC.
Neuroimage. 2020 Dec; 223: 117290.
The pontine-driven somatic gaze tract contributes to affective processing in humans.
Wong JJ, Chang DHF, Qi D, Men W, Gao JH, Lee TMC.
Neuroimage. 2020 Jun; 213: 116692.
A joint study of whole exome sequencing and structural MRI analysis in major depressive disorder.
Zhang Y, Li M, Wang Q, Hsu JS, Deng W, Ma X, Ni P, Zhao L, Tian Y, Sham PC, Li T.
Psychol Med. 2020 Feb; 50(3):384-395.
Associations of Weekday-to-Weekend Sleep Differences with Academic Performance and Health-Related Outcomes in School-age Children and Youths.
Sun W, Ling J, Zhu X, Lee TMC, Li SX.
Sleep Medicine Reviews. Sleep Med Rev. 2019 Aug; 46:27-53.
Promoting memory consolidation during sleep: A meta-analysis of target memory reactivation.
Hu X, Cheng L, Chiu M, & Paller KA.
Psychological Bulletin. 146(3):218-244 · November 2019
A visual circuit related to habenula underlies the antidepressive effects of light therapy.
Huang L, Xi Y, Peng Y, Yang Y, Huang X, Fu Y, Tao Q, Xiao J, Yuan T, An K, Zhao H, Pu M, Xu F, Xue T, Luo M, So KF, and Ren C.
Neuron. 2019 Apr 3; 102(1):128-142.e8.
Multivoxel pattern analysis reveals dissociations between subjective fear and its physiological correlates.
Taschereau-Dumouchel V, Kawato M, Lau H.
Mol Psychiatry. 2019 Oct 29. doi: 10.1038/s41380-019-0520-3.
Polygenic risk score increases schizophrenia liability through cognition-relevant pathways.
Toulopoulou T, Zhang X, Cherny S, Dickinson D, Berman KF, Straub RE, Sham P, Weinberger DR.
Brain. 2019 Feb 1; 142(2):471-485.
Can fMRI discriminate between deception and false memory? A meta- analytic comparison between deception and false memory studies.
Yu J, Tao Q, Zhang R, Chan CCH, Lee TMC.
Neurosci Biobehav Rev. 2019 Sep; 104:43-55.
Determinants of physical, mental, and social well-being: a longitudinal environment-wide association study.
Ni MY, Yao XI, Cheung F, et al.
Int J Epidemiol. 2019 Dec 23. pii: dyz238.
Loneliness and depression dissociated on parietal-centered networks in cognitive and resting states.
Shao R, Liu HL, Huang CM, Chen YL, Gao M, Lee SH, Lin C, Lee TMC.
Psychol Med. 2019 Oct 16:1-11.
The relationship between rumination and autobiographical memory specificity in people with depression.
Cheung MSL, Sin ELL, Lam M, Lee TMC.
Neuropsychiatry. 2018; 8(4): DOI: 10.4172/Neuropsychiatry.1000460
Effect of Damaging Rare Mutations in Synapse-Related Gene Sets on Response to Short-term Antipsychotic Medication in Chinese Patients With Schizophrenia: A Randomized Clinical Trial.
Wang Q, Man Wu H, Yue W, Yan H, Zhang Y, Tan L, Deng W, Chen Q, Yang G, Lu T, Wang L, Zhang F, Yang J, Li K, Lv L, Tan Q, Zhang H, Ma X, Yang F, Li L, Wang C, Ma X, Zhao L, Ren H, Yu H, Wang Y, Hu X, Zhang D, Sham P, Li T; Chinese Antipsychotics Pharmacogenomics Consortium.
JAMA Psychiatry. 2018 Dec 1; 75(12):1261-1269.
Fear extinction reverses dendritic spine formation induced by fear conditioning in the mouse.
Lai CSW, Adler A, Gan WB. auditory cortex.
PNAS. 2018; 115(37):9306-9311.
Ketamine and selective activation of parvalbumin interneurons inhibit stress-induced dendritic spine elimination.
Ng LHL, Huang Y, Chang RCC, Chan YS, and Lai CSW.
Translational Psychiatry. 2018 Dec 10; 8(1):272.
A community-based study of sleep and cognitive development in infants and toddlers.
Sun W, Li SX, Jiang Y, Xu X, Spruty K, Zhu Q, Tseng C, Jiang F.
Journal of Clinical Sleep Medicine. 2018 Jun 15; 14(6):977-984.
Eveningness chronotype, insomnia symptoms and emotional and behavioural problems in adolescents.
Li SX, Chan NY, Yu MWM, Lam SP, Zhang J, Chan JWY, Li AM, Wing YK.
Sleep Medicine. 2018 Jul; 47:93-99.
Analysis of genome-wide association data highlights candidates for drug repositioning in psychiatry.
So HC, Chau CK, Chiu WT, Ho KS, Lo CP, Yim SH, Sham PC.
Nat Neurosci. 2017 Oct; 20(10):1342-1349.
Sustainability of treatment effect of a 3-year early intervention programme for first-episode psychosis.
Chang WC, Kwong VWY, Lau ESK, So HC, Wong CSM, Chan GHK, Jim OTT, Hui CLM, Chan SKW, Lee EHM, Chen EYH.
Br J Psychiatry. 2017 Jul; 211(1):37-44.
Robust and rapid algorithms facilitate large-scale whole genome sequencing downstream analysis in an integrative framework.
Li M, Li J, Li MJ, Pan Z, Hsu JS, Liu DJ, Zhan X, Wang J, Song Y, Sham PC.
Nucleic Acids Res. 2017 May 19; 45(9):e75.
Dual-utility NLS drives RNF169-dependent DNA damage responses.
An L, Jiang Y, Ng HH, Man EP, Chen J, Khoo US, Gong Q, Huen MS.
Proc Natl Acad Sci U S A. 2017 Apr 4; 114(14):E2872-E2881.
A retinoraphe projection regulates serotonergic activity and looming-evoked defensive behaviour.
Huang L, Yuan T, Tan M, Xi Y, Hu Y, Tao Q, Zhao Z, Zheng J, Han Y, Xu F, Luo M, Sollars PJ, Pu M, Pickard GE, So KF, Ren C.
Nat Commun. 2017 Mar 31;8:14908.
The interaction of perceived control and gambler’s fallacy in risky decision making: An fMRI study.
Shao R, Sun D, Lee TMC.
Human Brain Mapping. 2016; 37: 1218-1234.
Loneliness in late-life depression: Structural and functional connectivity during affective processing.
Wong NML, Liu HL, Lin C, Huang CM, Wai YY, Lee SH, Lee TMC.
Psychological Medicine. 2016 Jun 22:1-15.
Mild reinforcement learning deficits in patients with first-episode psychosis.
Chang WC, Waltz JA, Gold JM, Chan TCW, Chen EYH.
Schizophrenia Bulletin. 2016 Nov; 42(6):1476-1485.
A pontine region is a neural correlate of the human affective processing network.
Lee TMC, Sun DL, Wong NML, Shao R, Men W, Ge J, So KF, Gao JH, Chan CCH.
EbioMedicine. 2015 Oct 20;2(11):1799-1805.
Neural mediator of the schizotypy-antisocial behavior relationship.
Lam BYH, Yang Y, Raine A, Lee TMC.
Translational Psychiatry. 2015 Nov 3; 5:e669.
Optimal duration of an early intervention programme for first-episode psychosis: randomised controlled trial.
Chang WC, Chan GHK, Jim OTT, Lau ESK, Hui CLM, Chan SKW, Lee EHM, Chen EYH.
British Journal of Psychiatry. 2015; 206 (6):492-500.
10-year outcome study of an early intervention program for psychosis compared with standard care service.
SKW Chan, HC So, CLM Hui, WC Chang, EHM Lee, DWS Chung, S Tso, SF Hung, KC Yip, E Dunn, EYH Chen.
Psychological Medicine. 2015; 45(6):1181-1193.
Diffusivity of the uncinate fasciculus in heroin users relates to their levels of anxiety.
Wong NML, Cheung S-H, Chan CCH, Zeng H, Li Y-P, So K-F, and Lee TMC.
Transl Psychiatry. 2015 Apr 28; 5:e554.
Dietary supplementation with n-3 fatty acids from weaning limits brain biochemistry and behavioural changes elicited by prenatal exposure to maternal inflammation in the mouse model.
Li Q, Leung YO, Zhou I, Ho LC, Kong W, Basil P, Wei R, Lam S, Zhang X, Law AC, Chua SE, Sham PC, Wu EX, McAlonan GM.
Translational Psychiatry. 2015 Sep 22; 5:e641. doi: 10.1038/tp.2015.126.
Can the neural–cortisol association be moderated by experience-induced changes in awareness?
Lau WKW, Leung MK, Chan CCH, Wong SSY, Lee TMC.
Scientific Reports. 2015 Nov 18; 5:16620.
Increased co-expression of genes harboring the damaging de novo mutations in Chinese schizophrenic patients during prenatal development.
Wang Q, Li M, Yang Z, Hu X, Wu HM, Ni P, Ren H, Deng W, Li M, Ma X, Guo W, Zhao L, Wang Y, Xiang B, Lei W, Sham PC, Li T.
Scientific Reports. 2015 Dec 15; 5:18209.